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The Quality in Organ Donation (QUOD) initiative aims to identify pathways of injury and repair in donors organs.

© © NDS

Despite the advances made in recent years in the realms of organ donation and transplantation, a significant and widening disparity exists between organ supply and demand. This disparity is predicted to worsen over the course of the next decade making this the biggest challenge facing the transplant community today. 

The QUOD initiative is led by Professor Rutger J Ploeg, Professor of Transplant Biology and Consultant Transplant Surgeon.

Despite the increasing awareness of the importance of transplantation there is a widening deficit between organ supply and clinical need. This pattern that is predicted to worsen over the next 10 years.

To address this disparity the transplant community has been turning to organs previously considered unsuitable for transplantation. This has included obtaining organs from extended criteria donors (older heart beating donors with additional co-morbidities) and non-heart beating donors. 

The QUOD initiative aims to identify pathways of injury and repair in donors organs, identifying biomarkers which can be used to predict the outcomes of transplantation. The initiative also aims to be a platform for investigating interventional strategies in the donor, that can improve the outcomes of transplantation.  

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Selected publications


Oxford and Newcastle receive £1.7m for vital biobank expansion

A multi-disciplinary team of researchers in Oxford and Newcastle, led by Professor Rutger Ploeg from the Nuffield Department of Surgical Sciences, has been awarded a grant of £1.7 million from the Medical Research Council. The four-year grant will enable the expansion of the successful Quality in Organ Donation (QUOD) initiative, currently funded and supported by NHS Blood and Transplant.

Related research themes