The Quality in Organ Donation (QUOD) programme provides a unique resource to facilitate research in organ donation and transplantation.
The Quality in Organ Donation (QUOD) initiative aims to identify pathways of injury and repair in donors’ organs.
Despite the advances made in recent years in the field of organ donation and increased awareness of the importance of transplantation, a significant and widening disparity exists between organ supply and demand. This disparity is predicted to worsen making this the biggest challenge facing the transplant community today.
To address this, the transplant community has been turning to organs previously considered unsuitable for transplantation. This has included organs donated from extended criteria donors who may be older or have pre-existing medical conditions. However, further research is required to improve our knowledge and optimise the outcomes for these organs.
The Quality in Organ Donation (QUOD) programme is a unique resource that facilitates transplant research, hosted by the University of Oxford, working in partnership with NHS Blood and Transplant (NHSBT) and academic transplant centres. QUOD is a national consortium working together with Newcastle University, all National Organ Retrieval Service teams, Specialist Nurses in Organ Donation and 61 hospitals across the UK.
QUOD is a national biobank, bringing together:
- A bioresource to match blood, urine and tissue samples
- Clinical data on donor management, organ retrieval and preservation, organ function post-transplant and recipient outcome
- Molecular diagnostics and translational analysis platforms
Key aims of QUOD
- Identify pathways of injury and apply novel, targeted interventions to repair donor organ injury.
- Optimise donor management and organ preservation to benefit patients.
- Translate validated experimental methods and technologies into clinical use and best practice protocols.
- Validate biomarkers and functional parameters to better predict outcomes following transplantation.
- Streamline and promote collaboration and dissemination between scientific and clinical experts in academic institutions across the United Kingdom.
QUOD has collected more than 125,000 samples from over 7,000 donors. More than 80 research project applications have been received, with over 65 having been approved by the QUOD Steering Committee and over 38,000 samples have been supplied to researchers. The latest QUOD statistics can be found on our website.
Studies supported by QUOD resources have yielded numerous publications, doctoral dissertations, and conference presentations spanning proteomics, genomics, immunology, and other disciplines.
Research projects have been conducted throughout the UK as well as in the United States, the Netherlands, and Germany, and QUOD has been engaged to support research with a range of high-level projects including the OrQA project, the SIGNET trial, the Human Cell Atlas, the PITHIA trial, UK Renal Imaging Network, REMAP-CAP and RECOVERY trials.
QUOD celebrates 10 years!
This year marks ten years of the QUOD programme. QUOD is celebrating this milestone throughout 2023, capping off the year with our 7th National Symposium which is scheduled to take place at Exeter College in Oxford on Friday 8 December. We look forward to welcoming you to this event.
Evolution of the QUOD box
Celebrating our ten year milestone has also been a time for reflection. QUOD has put together a video and blog post to show how the QUOD box has changed over the years.
Read the latest edition of the QUOD newsletter
Keep up-to-date with all things QUOD through our triannual newsletter. With each new edition, you can read all about the latest scientific, collaborative and research updates, as well as hear from our researchers about the most recent conference attendances and learn more about the wider QUOD team through questionnaires and our 'Spotlight on a QUOD Colleague' interviews.