Surgical Intervention Trials Unit (SITU)
Currently, less than 5% of government funding for medical research goes into surgery
One of only nine Royal College of Surgeons specialist trial centres across the whole of the UK, SITU is a collaboration between the Nuffield Department of Surgical Sciences (NDS) and the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). We have an extensive portfolio of surgical trials and welcome expressions of interest from potential new researchers.
More information about NDS SITU and our work within surgical research can be found by following the links below.
About Us
Our Surgical Trials
Work With Us
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NDS SITU Mission Statement |
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NDS SITU Core Principle |
| We design, develop, and deliver high quality, innovative and impactful surgical trials using novel methodologies and technologies to shape the future of trial-based research and pave the way for evolution in clinical practice. | We have established a nurturing environment that promotes continuous learning and development for all of our staff and collaborators, and together we have an unfaltering dedication to implementing meaningful improvements in patient care and experience. |
The NDS SITU team
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Sheraz Markar
Professor of Upper Gastrointestinal Surgery and Director of NDS SITU
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Michael Douek
Professor of Surgical Sciences & Breast Cancer, Academic Director of NDS SITU
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Charles Malyon
Clinical Trial Manager
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Alice Guazzelli
Clinical Trial Manager
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Melody Chin
Clinical Trial Manager - DISCUS
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Laura Lloyd Jones
Clinical Data Manager
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Martyn Hill
Statistician
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Alison Horne
Data Manager
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Sarah Crosweller
Clinical Trial Manager
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Sian Saul
Clinical Data Manager
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Mahesha Beckford-Britton
Clinical Trials Assistant
Latest News
The NIHR recently interviewed Rachel Rolph, Chief Investigator of the Restore-B trial into whether mesh should be used in breast reconstruction after surgery for breast cancer. Read the Q&A.
Latest publications
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Local anaesthetic transperineal biopsy versus transrectal prostate biopsy in prostate cancer detection (TRANSLATE): a multicentre, randomised, controlled trial.
Journal article
Bryant RJ. et al, (2025), Lancet Oncol, 26, 583 - 595
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Statistical analysis plan for the TRANSLATE (TRANSrectal biopsy versus Local Anaesthetic Transperineal biopsy Evaluation of potentially clinically significant prostate cancer) multicentre randomised controlled trial
Preprint
Marian IR. et al, (2025)
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Radiofrequency thalamotomy for tremor outcomes correlate with dentorubrothalamic tract distance.
Journal article
Shaikh AA. et al, (2025), Br J Neurosurg, 1 - 10
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It's beginning to smell a lot like Christmas: An olfactory local field potential study of the insula.
Journal article
Raghu ALB. et al, (2025), Clin Neurophysiol, 173, 163 - 165