Surgical Intervention Trials Unit (SITU)
Currently, less than 5% of government funding for medical research goes into surgery
One of only nine Royal College of Surgeons specialist trial centres across the whole of the UK, SITU is a collaboration between the Nuffield Department of Surgical Sciences (NDS) and the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences (NDORMS). We have an extensive portfolio of surgical trials and welcome expressions of interest from potential new researchers.
More information about NDS SITU and our work within surgical research can be found by following the links below.
About Us
Our Surgical Trials
Work With Us
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NDS SITU Mission Statement |
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NDS SITU Core Principle |
| We design, develop, and deliver high quality, innovative and impactful surgical trials using novel methodologies and technologies to shape the future of trial-based research and pave the way for evolution in clinical practice. | We have established a nurturing environment that promotes continuous learning and development for all of our staff and collaborators, and together we have an unfaltering dedication to implementing meaningful improvements in patient care and experience. |
Latest News
The NIHR recently interviewed Rachel Rolph, Chief Investigator of the Restore-B trial into whether mesh should be used in breast reconstruction after surgery for breast cancer. Read the Q&A.

Latest publications
ssociation between deep cervical lymph node dissection and dementia incidence in patients with head and neck cancer: a systematic review
Journal article
Omar M. et al, (2026), European Journal of Plastic Surgery, 49
Resilience Engineering concepts, Safety-II language, FRAM practice, and co-creating communities: how Hollnagel reshaped patient safety
Journal article
Sujan M. et al, (2026), Safety Science, 200
Shaping the Future of AI in Organ Transplantation: Position Paper of the European Society for Organ Transplantation (ESOT)
Journal article
Kourounis G. et al, (2026), Transplant International
Stimulation of the human periaqueductal gray induces threat bradycardia: a case report
Journal article
Klaassen FH. et al, (2026), Neurocase, 1 - 11