Contact information
Research groups
Jessica Scaife
BSc (Hons) PhD PGCE
Operational Lead for NDS SITU
I am Operational Lead for NDS SITU, overseeing a portfolio of surgical clinical trials in the areas of urology (PROMOTE, PART and TRANSLATE), Transplant (NKP-1, TWO and SENTINEL), cardiology (ART) breast cancer (ENDONET), and device trials in ophthalmology and deep brain stimulation. I oversee the portfolio with Amy Taylor and work closely with the director of SITU, Michael Douek, and the deputy directors, Richard Bryant, Sheraz Markar and Alex Green.
I am involved in the development of new grant applications, the setting up of new trials and provide ongoing management and guidance to trials at all stages. I am responsible for helping the trial managers meet their trial milestones and work closely with the trial CIs to ensure trials are delivered to a high standard.
I have been in research for over two decades. I hold an honours degree in neuroscience and a PhD in psychopharmacology from Nottingham University. I have worked at the University of Sussex and spent the last nine years in the Department of Psychiatry here in Oxford. During my postdoctoral career, I have gained broad range of experience investigating brain function in both patient populations and healthy volunteers, using MRI and MEG. I managed a number of experimental medicine studies, phase 3 clinical trials and a device trial in collaboration with industrial partners. I am also a trained secondary science teacher and was Head of Biology before returning to research in 2013. I am passionate about public engagement and I am an In2Science mentor to encourage students into STEM.
Recent publications
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Effects of ulotaront on brain circuits of reward, working memory, and emotion processing in healthy volunteers with high or low schizotypy.
Journal article
Perini F. et al, (2023), Schizophrenia (Heidelb), 9
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Catechol-O-methyltransferase activity does not influence emotional processing in men.
Journal article
Martens MA. et al, (2022), J Psychopharmacol
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Deep brain stimulation of the nucleus accumbens in severe enduring anorexia nervosa: a pilot study
Journal article
SCAIFE J. et al, (2022), Frontiers in Behavioral Neuroscience
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A Longitudinal Magnetoencephalographic Study of the Effects of Deep Brain Stimulation on Neuronal Dynamics in Severe Anorexia Nervosa.
Journal article
Braeutigam S. et al, (2022), Front Behav Neurosci, 16
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Translating the promise of 5HT4 receptor agonists for the treatment of depression.
Journal article
Murphy SE. et al, (2021), Psychol Med, 51, 1111 - 1120