Jessica Scaife
PhD
Research Manager
I have over twenty years experience designing experimental paradigms. A Neuropsychopharmacologist and Cognitive Neuroscientist, my research combines neuroimaging, electrophysiology and stimulation to investigate the neural and pharmacological basis of reward and emotion. During my 20 year postdoctoral career, I investigated brain function in both patient populations and healthy volunteers, using MRI and MEG. I ran studies in experimental medicine, Phase 1 and 3 clinical trials, including deep brain stimulation with Alex Green. I use mixed methods research to capture the lived experience of patients.
A member of the MSD PPI network, I lead PPI throughout trial development, and beyond, I am committed to developing and fostering greater connections with patient partners and charities.
I am passionate about public engagement and encouraging students to consider careers in STEM through events and work experience.
Recent publications
The effect of acute angiotensin receptor blockade on subjective and biological markers of stress response.
Journal article
Shkreli L. et al, (2026), Psychoneuroendocrinology, 191
Effects on hippocampal activity following novel 5-HT4 receptor agonism in unmedicated patients with depression: the RESTAND study.
Journal article
de Cates AN. et al, (2026), Transl Psychiatry
Early effects of a novel 5-HT4R agonist (PF-04995274) and the SSRI citalopram on emotional cognition in unmedicated depression: RESTAND study.
Journal article
Gillespie AL. et al, (2026), Br J Psychiatry, 1 - 10
Cost Effectiveness of Local Anaesthetic Transperineal Versus Transrectal Biopsy: Results from the TRANSLATE Study.
Journal article
Little M. et al, (2026), Eur Urol Focus, 12, 227 - 236
Prepectoral no mesh versus mesh immediate implant-based reconstruction after mastectomy (Restore-B): a multicentre single-blinded randomised controlled feasibility study protocol.
Journal article
Rolph R. et al, (2025), BMJ Open, 15