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Department of Neurosurgery, West Wing, Level 3, John Radcliffe Hospital, Oxford OX3 9DU
I studied medicine at University College London qualifying MB BS in 1997. I obtained a first class honours in Neurosciences (intercalated) in 1994. After house jobs and a basic surgical rotation in the West Midlands, I entered Neurusurgical training in London then Oxford from 2002-2009. I completed a MD degree in Oxford in the role of the periaqueductal grey area in autonomic control during this time. I became a consultant neurosurgeon in 2009. I am currently president of the British Society for Stereotactic and Functional Neurosurgery (BSSFN).
Awards Training and Qualifications
- FRCS (SN) Royal College of Surgeons of England2007
- Doctor of Medicine University of London 2005- 2007
- MB BS University College London 1991- 1997
- BSc (Hons) University College London 1994
- New Investigator Award International Neuromodulation Society 2010
- 7th Cluster Headache Award International Annual Convention on Cluster Headache 2010
- Stereotactic and Functional Neurosurgery Resident Award Congress of Neurological Surgeons (USA) 2005
- Gordon Holmes Prize Royal Society of Medicine 2005
Spalding Associate Professor
- Consultant Neurosurgeon
Over the past six years I have been looking at the neurocircuitry underlying autonomic function and pain in humans undergoing Deep Brain Stimulation (DBS). There are several aims of this research. Firstly, I wish to understand both the mechanisms underlying the pathophysiology of neuropathic pain as well as why some patients get much better than results than others. Secondly, by understanding the autonomic nervous system, it may be possible to control diseases such as hypertension, respiratory and bladder disease by brain manipulation in the future. Most of the research to date has involved stimulating brain areas under different experimental conditions and also recording local field potentials to understand the underlying neurophysiology. This work has resulted in a number of publications including improvement in peak expiratory flow with stimulation, the effect of stimulation on blood pressure and baroreceptors sensitivity and novel electrical signals associated with pain states.
Sources of Funding
- BRC 2009-2014
- British Heart Foundation 2011-2012
- European Union FP7 2012-2015
Neurophysiological characteristics in the periventricular/periaqueductal gray correlate with pain perception, sensation, and affect in neuropathic pain patients.
Luo H. et al, (2021), Neuroimage Clin, 32
Paired acute invasive/non-invasive stimulation (PAINS) study: A phase I/II randomized, sham-controlled crossover trial in chronic neuropathic pain.
Parker T. et al, (2021), Brain Stimul
Subthalamic dynamic neural states correlate with motor symptoms in Parkinson's Disease.
Nie Y. et al, (2021), Clin Neurophysiol, 132, 2789 - 2797
Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus.
He S. et al, (2021), J Neurosci
Pallido-putaminal connectivity predicts outcomes of deep brain stimulation for cervical dystonia.
Raghu ALB. et al, (2021), Brain