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Radionuclide Radiobiology

The Radionuclide Radiobiology group seeks to understand how cells and tissues respond to radionuclide based therapies to improve outcomes for patients treated with theranostics.

Machine used for treatment

Our key research interests include:

  • Investigating the different senescence outcomes and the implications for re-treatment,
  • Identifying when is best to use alpha and beta based radionuclide therapies,
  • Understanding how differences in cellular metabolism affect radiobiological response,
  • Novel drug combinations with radionuclide based therapies.

Since radionuclide based therapies are inherently a spatially-based treatment we use a combination of advanced 3D in vitro models and preclinical imaging to understand and exploit the opportunities that may come from the heterogeneous uptake of radionuclide based therapies. Our group is currently primarily focused on understanding the radiobiology of metastatic prostate cancer, its metabolic phenotypes and contextual differences in radiobiological response. There are also key unknowns in the normal tissue radiobiology between high LET (alpha) and low LET based therapies (Gamma and Beta). We are investigating ways to minimise the impact of novel alpha-based therapies by investigating the impact of dose-rate and drug combinations.

Our work is supported by Prostate Cancer UK, Prostate Cancer Foundation Challenge Award, John Black Foundation and The Urological Foundation.

Collaborators

Professor Ian Mills (NDS)
Professor Claire Edwards (NDS)
Professor Katherine Vallis and DPhil student Mia Dobbing (Department of Oncology)
Professor James McCullagh (Department of Chemistry)

External collaborators 

Dr Mark Salji (University of Glasgow)
Dr Victoria Dunne (Queen's University Belfast)

Our team

Centres

Underpinning platforms

Resources for Researchers

Explore our collection of resources useful to researchers in all parts of the research process, from experimental techniques to publication and review.

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Funding

Research carried out at the NDS has been generously funded by a wide range of sponsors. 

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Research Themes

Related research themes

Cancer
Cancer