Oxford Transplant Biobank (OTB)
The Oxford Transplant Biobank (OTB) supports hypothesis driven research in the fields of organ donation, pre-transplant dialysis and transplantation.
OTB supports translational research through a repository of samples from living donors, patients on dialysis and recipients of transplants originating from either living or deceased donations performed at the Oxford Transplant Centre.
OTB was set up in 2016 as a counterpart to its sister bioresource ‘QUOD’, the Quality in Organ Donation biobank (www.quod.org.uk). Based at the Oxford Transplant Centre, OTB is a collaboration between Oxford University Hospitals NHS Foundation Trust and the Nuffield Department of Surgical Sciences.
Anonymised samples and associated clinical data are available for research aimed at improving transplantation outcomes. This includes studies on:
- Donor management
- Organ preservation
- Ischaemia reperfusion injury
- Biomarker identification and development
- Surgical techniques and peri-operative management of donors and recipients
- Post transplantation management including immunosuppression, dialysis and tolerance
- Histocompatibility and immunogenetics
Samples are collected from the beginning of the theatre procedure right through to recipient recovery on the ward and subsequent follow-up appointments in clinic. Living donor samples are also collected during the donation procedure.
Samples collected include blood, urine and tissue which are systematically processed and stored at the Churchill and John Radcliffe Hospitals.
OTB has collected more than 8,800 samples from over 565 donors, consisting of >6,500 blood/urine samples and >2,300 tissue samples. To date OTB has supported 10 research projects.
OTB operates under the University of Oxford HTA licence (12217) and its own Research Ethics Committee approval (19/SC/0529).
Through QUOD and OTB, researchers can access samples and data spanning the entire transplant lifeline.
We invite Oxford academics and their collaborative partners interested in using our samples and associated data to contact us at otbcontact@nds.ox.ac.uk for further details.
Principal Investigator
Meet the team
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Sarah Cross
QUOD National Operational Coordinator and Oxford Transplant Biobank Manager
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Sushma Shankar
NIHR Clinical Lecturer in General Surgery & Transplantation
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Philippa Wren
PA to Professor Rutger Ploeg, QUOD and Transplant Research Administrator
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Laima Khan
Transplant Technician
