- 2nd prize for the European Society of Organ Transplantation (ESOT) Leonardo da Vinci Innovation Award, ESOT 2019 Congress - read the story on the NDS news pages
NIHR Clinical Lecturer in General Surgery & Transplantation
I am a transplant surgeon in training and also conduct post-doctoral research within the Transplantation Research and Immunology Group. My work focuses on the roles of human B regulatory cells (Breg) in both health and disease. Breg have been shown to be protective in solid organ transplantation and autoimmune disease, whilst promoting disease progression in conditions such as infection and cancer.
At TRIG, we have developed novel methods to generate human Breg in vitro. This enables us to study this exciting cell population in great detail. We are currently interrogating mechanisms by which Breg function in vivo, in clinically relevant humanised mouse models of skin transplantation, to better understand them as a potential cellular therapy. In an innovative new project, we are also investigating the function of human Breg in the progression of pancreatic cancer. This work is funded by the Wellcome Trust, Royal College of Surgeons, Oxfordshire Health Services and the Oxford Transplant Foundation.
Neutralising antibodies after COVID-19 vaccination in UK haemodialysis patients.
Carr EJ. et al, (2021), Lancet
Regulatory B cells in transplantation: Roadmaps to clinic.
Beckett J. et al, (2020), Transpl Int
Caught in the crossfire: hepato-bilio-pancreatic cancer surgery in the midst of COVID-19.
Rompianesi G. et al, (2020), Br J Surg
Ex Vivo-Expanded Human CD19(+)CD73(-)CD25(+)CD71(+)TIM-1(+)B Regulatory Cells Can Prolong Allograft Survival in a Humanized Mouse Model of Skin Transplantation and Are Dependent on TIM-1-Mediated Regulation of STAT3 Signaling.
Shankar S. et al, (2018), AMERICAN JOURNAL OF TRANSPLANTATION, 18, 440 - 440
International Medical Graduates in Abdominal Transplant Surgery Fellowships in the United States, response to letter by Schlottmann et al.
Lafranca JA. et al, (2018), Transpl Int, 31, 568 - 569