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We are investigating the role of regulatory T cells (Tregs) in the induction of long-term allograft survival and how specific pathways can be manipulated to orchestrate transplantation tolerance. Specifically, a focus on the axis between interleukin-33 (IL-33) and its receptor ST2 and how they modulate Treg activity. Additionally, in collaboration with the Ratcliffe Group of the Nuffield Department of Medicine (Oxford) we are investigating the role of Hypoxia-Inducible Factors (HIFs) within Tregs. It is thought that elucidating ways to manipulate Treg activity through different pathways, such as the IL-33/ST2 axis and HIF, may be the key to harnessing the induction of specific immunologic tolerance.