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John Radcliffe Hospital, Level 5 and 6, Headley Way, Headington, Oxford, OX3 9DU

DPhil start date

1 October 2016

Project title

CCR4 and its importance in regulatory T cell function


Dr Joanna Hester, Dr Fadi Issa and Professor Kathryn Wood

George Adigbli

BSc (Hons) MBBS MSc MRCS (Eng)

DPhil student

I qualified in Medicine from University College London and have completed a BSc in Immunology and Cell Pathology and an MSc in Burns, Plastic and Reconstructive Surgery.

I am currently undertaking a DPhil within the Transplantation Research Immunology Group headed by Professor Kathryn Wood. My research broadly focuses on examining the roles of the CCR4 receptor in regulatory T cells (Treg) and also on the effects of synthetic receptors on Treg function. 

Solid organ transplantation is currently the best treatment option for patients with terminal organ failure. Whereas immunosuppressive drugs have demonstrated success in reducing the incidence of acute rejection, they produce severe toxic side-effects including malignancy, cardiotoxicity and nephrotoxicity. Understanding natural immune mechanisms that promote transplant tolerance without rendering the immune system impotent may lead to the development of safer therapies. Treg represent a cell population dedicated to the function of immune suppression. They have been the subject of research within our group for several years as they afford potential targets for clinical interventions against transplant rejection.