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DPHIL START DATE

October 2020

PROJECT TITLE

An exploration of post-transplantation γδ T cell phenotype and function

SUPERVISORS

Dr Joanna Hester and Professor Fadi Issa 

Oliver McCallion

BMBS, PGDip, AKC, MRCS.


DPhil candidate and Clinical Research Fellow

  • Clinical Teaching Associate – Exeter College

Generating a granular description of immunological rejection following transplantation is key to developing novel immunosuppressive strategies. During my DPhil I aim to characterise where a subset of unconventional lymphocytes—γδ T cells—are mechanistically situated in transplant rejection in order to modulate their cascade through targeted intervention. γδ T cells are of particular interest in this setting due to their MHC-unrestricted recognition of antigen, promulgation of damaging downstream immune responses, and functional heterogeneity. I plan to use several techniques during my DPhil including in vitro assays, bulk and single cell NGS, and in situ transcriptomics to longitudinally describe the γδ T cell compartment following kidney transplantation. My work is generously supported by both a Medical Research Council Clinical Research Training Fellowship, and a Royal College of Surgeons Research Fellowship. 

Alongside my research I enjoy medical education. I currently work as a Clinical Teaching Associate at Exeter College providing tutorials for medical students, am a divisional examiner for Medical Sciences at the Oxford Learning Centre, and give regular seminars and laboratory workshops in anatomy and paediatrics. I have supervised small undergraduate and masters-level projects in the past, many of which have gone on to be presented or published, and am always very happy to be emailed to discuss collaboration or supervision requests.  

Recent publications

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