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Congratulations to Academic Clinical Lecturer Dr Fadi Issa who has been awarded a four-year Wellcome Trust Clinical Research Career Development Fellowship in support of his project entitled ‘Investigation of hypoxia-sensing mechanisms in immune regulation’.
Alberto Lens Pardo
BSc, MSc, PhD Alberto Lens Pardo - Postdoctoral Scientist in Organoid Biology & Multiomics
Ashok Handa
MBBS, MA, FRCS (Eng), FRCS(Ed) Ashok Handa - Professor of Vascular Surgery and Director of Teaching in Surgery
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS Alex Gordon-Weeks - Consultant Hepatobiliary Surgeon and Clinical Lecturer
Freddie Hamdy CBE
MBChB, LRCP-LRCSEd, LRCPSGlasg, FRCSEd, FRCSEng, MD (Shef), MA (Oxon) FRCSEd (Urol), FMedSci Freddie Hamdy CBE - Head of Department
Meet the researcher
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Fadi Issa
Professor of Transplantation, Associate Head & Surgical Sciences Theme Lead
Project summary
How does the immune system respond to changes in oxygen levels?
Our immune system has an astounding ability to respond to infections while remaining tolerant towards our own cells. This equilibrium is maintained when we are healthy. However, a breakdown can result in an immune imbalance and the inability to respond appropriately to infections and tumours, as well as the development of autoimmune diseases. The factors responsible for this balance are not yet fully understood, but may be related to how T cells respond to low levels of oxygen. In order to investigate this, Dr Issa will use genetically altered cells that behave as if they are in a low oxygen environment. Studying the way in which these cells perform will provide valuable insight into diseases of immune dysfunction and open up the possibilities for manipulating immune cells to produce better outcomes for patients with transplants, autoimmune diseases, and perhaps cancer.