Collaborators
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Simon Buczacki
Richard Blackwell Pharsalia Professor of Colorectal Surgery
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Peter Friend
Emeritus Professor of Transplantation
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Hussain Abbas
DPhil Student and Clinical Research Fellow in Transplant Surgery
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Fungai Dengu
Academic Clinical Lecturer in Transplant Surgery
Research groups
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
- Surgical Specialty Lead for Colorectal Liver Metastase, Royal College of Surgeons of England
Liver Cancer Biology Group
Research Interests
Spatial biology of primary and metastatic liver cancers.
Hemi-liver perfusion as a novel liver cancer model.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
Clinical Interests
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced liver cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Primary and metastatic liver cancers.
Pancreatic cancer.
Cholangiocarcinoma.
Awards
2025 CRUK Discovery Programme Award
2022 CRUK Oxford Cancer Development Fund
Key publications
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Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Journal article
Yuzhalin AE. et al, (2018), Nat Commun, 9
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FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Journal article
Im JH. et al, (2020), Nat Commun, 11
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Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Journal article
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935
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Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Journal article
Lim SY. et al, (2016), Oncogene, 35, 5735 - 5745
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Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis.
Journal article
Zhao L. et al, (2013), Hepatology, 57, 829 - 839
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Targeting the CCL2-CCR2 signaling axis in cancer metastasis.
Journal article
Lim SY. et al, (2016), Oncotarget, 7, 28697 - 28710
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A core matrisome gene signature predicts cancer outcome.
Journal article
Yuzhalin AE. et al, (2018), Br J Cancer, 118, 435 - 440
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Cancer Extracellular Matrix Proteins Regulate Tumour Immunity.
Journal article
Gordon-Weeks A. and Yuzhalin AE., (2020), Cancers (Basel), 12
Recent publications
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Ex vivo model of functioning human lymph node reveals role for innate lymphocytes and stroma in response to vaccine adjuvant.
Journal article
Fergusson JR. et al, (2025), Cell Rep, 44
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Iatrogenic Subcapsular Haematoma Leads to 151% Growth of Future Liver Remnant.
Journal article
Fu H. et al, (2025), Cardiovasc Intervent Radiol
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Simultaneous versus delayed resection of synchronous colorectal liver metastases: A systematic review and meta-analysis.
Journal article
Lakha AS. et al, (2025), Eur J Surg Oncol, 51
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A commentary on: “Effect of Preoperative Autologous Blood Storage in Major Hepatectomy for Perihilar Malignancy: A Randomized Controlled Trial”
Journal article
Lakha AS. and Gordon-Weeks A., (2025), AME Surgical Journal, 5
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Radiomics for Treatment Planning in Liver Cancers.
Journal article
Mian A. et al, (2025), JAMA Surg
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Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control.
Journal article
Russell SN. et al, (2025), Gut