Contact information
alex.gordon-weeks@nds.ox.ac.uk
alex.gordon-weeks@ouh.nhs.uk
Phoebe Martin
Phoebe.Martin@ouh.nhs.uk
https://scholar.google.co.uk/citations?user=YTzL4ZoAAAAJ&hl=en
Collaborators
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Simon Buczacki
Richard Blackwell Pharsalia Professor of Colorectal Surgery
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Richard Bryant
Associate Professor of Urology and Academic Director of NDS SITU
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Peter Friend
Professor of Transplantation
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Katherine Gordon Quayle
Research Nurse
Research groups
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
Research Interests
Spatial biology of primary and metastatic liver cancers.
Hemi-liver perfusion as a novel liver cancer model.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
The cancer extracellular matrix.
Clinical Interests
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced colorectal cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Liver metastasis.
Pancreatic cancer.
Cholangiocarcinoma.
Key publications
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Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Journal article
Yuzhalin AE. et al, (2018), Nat Commun, 9
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FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Journal article
Im JH. et al, (2020), Nat Commun, 11
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Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Journal article
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935
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Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Journal article
Lim SY. et al, (2016), Oncogene, 35, 5735 - 5745
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Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis.
Journal article
Zhao L. et al, (2013), Hepatology, 57, 829 - 839
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Targeting the CCL2-CCR2 signaling axis in cancer metastasis.
Journal article
Lim SY. et al, (2016), Oncotarget, 7, 28697 - 28710
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A core matrisome gene signature predicts cancer outcome.
Journal article
Yuzhalin AE. et al, (2018), Br J Cancer, 118, 435 - 440
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Cancer Extracellular Matrix Proteins Regulate Tumour Immunity.
Journal article
Gordon-Weeks A. and Yuzhalin AE., (2020), Cancers (Basel), 12
Recent publications
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Autologous blood transfusion reduces the requirement for perioperative allogenic blood transfusion in patients undergoing major hepatopancreatobiliary surgery: a retrospective cohort study.
Journal article
Lakha AS. et al, (2023), Int J Surg, 109, 3078 - 3086
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The safety of telemedicine clinics as an alternative to in-person preoperative assessment for elective laparoscopic cholecystectomy in patients with benign gallbladder disease: a retrospective cohort study.
Journal article
Urbonas T. et al, (2023), Patient Saf Surg, 17
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Real-world practice of conversion surgery for unresectable hepatocellular carcinoma - a single center data of 26 consecutive patients.
Journal article
Zhang B. et al, (2023), BMC Cancer, 23
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Disappearing colorectal liver metastases in the era of state-of-the-art triple-modality diagnostic imaging.
Journal article
Kuhlmann KF. et al, (2023), Eur J Surg Oncol
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Long-term morbidity after surgery for perihilar cholangiocarcinoma: A cohort study.
Journal article
Gilbert TM. et al, (2022), Surg Oncol, 45
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Liquid biopsy in cholangiocarcinoma: Current status and future perspectives.
Journal article
Rompianesi G. et al, (2021), World J Gastrointest Oncol, 13, 332 - 350