Contact information
alex.gordon-weeks@nds.ox.ac.uk
alex.gordon-weeks@ouh.nhs.uk
Phoebe Martin
Phoebe.Martin@ouh.nhs.uk
https://scholar.google.co.uk/citations?user=YTzL4ZoAAAAJ&hl=en
Collaborators
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Simon Buczacki
Richard Blackwell Pharsalia Professor of Colorectal Surgery
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Richard Bryant
Associate Professor of Urology
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Peter Friend
Professor of Transplantation
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Katherine Gordon Quayle
Research Nurse
Research groups
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
Research Interests
Liver metastasis biology.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
The cancer extracellular matrix.
Clinical Interests
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced colorectal cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Liver metastasis.
Pancreatic cancer.
Cholangiocarcinoma.
Key publications
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Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Journal article
Yuzhalin AE. et al, (2018), Nat Commun, 9
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Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Journal article
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935
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FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Journal article
Im JH. et al, (2020), Nat Commun, 11
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A core matrisome gene signature predicts cancer outcome.
Journal article
Yuzhalin AE. et al, (2018), Br J Cancer, 118, 435 - 440
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Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.
Journal article
Lim SY. et al, (2015), Hepatology, 62, 521 - 533
Recent publications
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Liquid biopsy in cholangiocarcinoma: Current status and future perspectives.
Journal article
Rompianesi G. et al, (2021), World J Gastrointest Oncol, 13, 332 - 350
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Cancer Extracellular Matrix Proteins Regulate Tumour Immunity.
Journal article
Gordon-Weeks A. and Yuzhalin AE., (2020), Cancers (Basel), 12
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Investigating immune microenvironment effects of radiotherapy in pre-clinical prostate cancer models
Conference paper
Philippou Y. et al, (2020), RADIOTHERAPY AND ONCOLOGY, 152, S1015 - S1015
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Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Journal article
Philippou Y. et al, (2020), Br J Cancer, 123, 1089 - 1100
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The Diagnostic Accuracy of Mutant KRAS Detection from Pancreatic Secretions for the Diagnosis of Pancreatic Cancer: A Meta-Analysis.
Journal article
Patel N. et al, (2020), Cancers (Basel), 12