Collaborators
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Simon Buczacki
Richard Blackwell Pharsalia Professor of Colorectal Surgery
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Peter Friend
Professor of Transplantation
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Hussain Abbas
DPhil Student and Clinical Research Fellow in Transplant Surgery
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Fungai Dengu
Academic Clinical Lecturer in Transplant Surgery
Research groups
Alex Gordon-Weeks
MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
Liver Cancer Biology Group
Research Interests
Spatial biology of primary and metastatic liver cancers.
Hemi-liver perfusion as a novel liver cancer model.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
Clinical Interests
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced liver cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Primary and metastatic liver cancers.
Pancreatic cancer.
Cholangiocarcinoma.
Key publications
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Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Journal article
Yuzhalin AE. et al, (2018), Nat Commun, 9
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FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Journal article
Im JH. et al, (2020), Nat Commun, 11
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Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Journal article
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935
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Tumor-infiltrating monocytes/macrophages promote tumor invasion and migration by upregulating S100A8 and S100A9 expression in cancer cells.
Journal article
Lim SY. et al, (2016), Oncogene, 35, 5735 - 5745
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Recruitment of a myeloid cell subset (CD11b/Gr1 mid) via CCL2/CCR2 promotes the development of colorectal cancer liver metastasis.
Journal article
Zhao L. et al, (2013), Hepatology, 57, 829 - 839
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Targeting the CCL2-CCR2 signaling axis in cancer metastasis.
Journal article
Lim SY. et al, (2016), Oncotarget, 7, 28697 - 28710
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A core matrisome gene signature predicts cancer outcome.
Journal article
Yuzhalin AE. et al, (2018), Br J Cancer, 118, 435 - 440
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Cancer Extracellular Matrix Proteins Regulate Tumour Immunity.
Journal article
Gordon-Weeks A. and Yuzhalin AE., (2020), Cancers (Basel), 12
Recent publications
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Induction of macrophage efferocytosis in pancreatic cancer via PI3Kγ inhibition and radiotherapy promotes tumour control.
Journal article
Russell SN. et al, (2025), Gut
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Invasive intraductal oncocytic papillary neoplasms (IOPN) and adenocarcimoma arising from intraductal papillary mucinous neoplasms (A-IPMN) of the pancreas: comparative analysis of clinicopathological features, patterns of recurrence and survival: a multicentre study.
Journal article
Lucocq J. et al, (2024), HPB (Oxford)
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Precursor Epithelial Subtypes of Adenocarcinoma Arising from Intraductal Papillary Mucinous Neoplasms (A-IPMN): Clinicopathological Features, Recurrence and Response to Adjuvant Chemotherapy.
Journal article
Lucocq J. et al, (2024), Ann Surg Oncol
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Risk of Recurrence After Surgical Resection for Adenocarcinoma Arising From Intraductal Papillary Mucinous Neoplasia (IPMN) With Patterns of Distribution and Treatment: An International, Multicenter, Observational Study (ADENO-IPMN Study).
Journal article
Lucocq J. et al, (2024), Ann Surg, 280, 126 - 135
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Predictors of long-term survival after resection of adenocarcinoma arising from intraductal papillary mucinous neoplasm and derivation of a prognostic model: An international multicenter study (ADENO-IPMN study).
Journal article
Lucocq J. et al, (2024), Surgery
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Adjuvant chemotherapy for adenocarcinoma arising from intraductal papillary mucinous neoplasia: multicentre ADENO-IPMN study.
Journal article
Lucocq J. et al, (2024), Br J Surg, 111