MBChB, BSc, DPhil, FRCS
Consultant Hepatobiliary Surgeon and Clinical Lecturer
Liver metastasis biology.
Radiomics for cancer prognostication.
Regulation of tumour immunity.
The cancer extracellular matrix.
I work as an NHS surgeon within the University of Oxford Hospitals NHS Foundation Trust. I chair the advanced colorectal cancer multidisciplinary team meeting held at the Churchill Hospital site. The focus of my practice is malignant and benign hepatobiliary pathology inclusive of:
Colorectal cancer liver metastatic growth depends on PAD4-driven citrullination of the extracellular matrix.
Yuzhalin AE. et al, (2018), Nat Commun, 9
Neutrophils promote hepatic metastasis growth through fibroblast growth factor 2-dependent angiogenesis in mice.
Gordon-Weeks AN. et al, (2017), Hepatology, 65, 1920 - 1935
FGF2 alters macrophage polarization, tumour immunity and growth and can be targeted during radiotherapy.
Im JH. et al, (2020), Nat Commun, 11
A core matrisome gene signature predicts cancer outcome.
Yuzhalin AE. et al, (2018), Br J Cancer, 118, 435 - 440
Cd11b(+) myeloid cells support hepatic metastasis through down-regulation of angiopoietin-like 7 in cancer cells.
Lim SY. et al, (2015), Hepatology, 62, 521 - 533
Liquid biopsy in cholangiocarcinoma: Current status and future perspectives.
Rompianesi G. et al, (2021), World J Gastrointest Oncol, 13, 332 - 350
Cancer Extracellular Matrix Proteins Regulate Tumour Immunity.
Gordon-Weeks A. and Yuzhalin AE., (2020), Cancers (Basel), 12
Investigating immune microenvironment effects of radiotherapy in pre-clinical prostate cancer models
Philippou Y. et al, (2020), RADIOTHERAPY AND ONCOLOGY, 152, S1015 - S1015
Impacts of combining anti-PD-L1 immunotherapy and radiotherapy on the tumour immune microenvironment in a murine prostate cancer model.
Philippou Y. et al, (2020), Br J Cancer, 123, 1089 - 1100
The Diagnostic Accuracy of Mutant KRAS Detection from Pancreatic Secretions for the Diagnosis of Pancreatic Cancer: A Meta-Analysis.
Patel N. et al, (2020), Cancers (Basel), 12