I studied medicine at Cambridge and St Thomas’s Hospital and after qualifying trained as a surgeon in London and Cambridge before undertaking a period of research at the University of Cambridge under the supervision of Professor Sir Roy Calne.
In 1988 I was appointed Visiting Assistant Professor of Surgery at Indiana University Medical Center, USA, where I was responsible for initiating a programme of liver transplantation. I returned to the UK in 1989 to take up the post of University Lecturer (honorary consultant) in the University Department of Surgery at Cambridge. I was the Clinical Director of the Cambridge Transplant Unit and also a Fellow and Director of Studies in Medicine at Magdalene College, Cambridge. I was appointed to my current post in 1999.
Professor of Transplantation
- Consultant Transplant and HPB Surgeon
- Director Oxford Transplant Centre
My experimental interest is in the application of isolated perfusion of the liver to a number of therapeutic areas. In particular, perfusion of the liver with oxygenated blood at normal body temperature can allow recovery from damage, extended preservation for transplantation and organ specific delivery of therapy.
Clinical research studies include small scale pilot studies of novel immunosuppressive strategies and the organisation of a multi centre national trial.
A Back-to-Base Experience of Human Normothermic Ex Situ Liver Perfusion: Does the Chill Kill?
Bral M. et al, (2019), Liver Transpl, 25, 848 - 858
Normothermic Machine Perfusion (NMP) Inhibits Proinflammatory Responses in the Liver and Promotes Regeneration.
Jassem W. et al, (2018), Hepatology
Exploring the Structural and Functional Effects of Normothermic Machine Perfusion and DeFatting Interventions on Human Steatotic Livers
Ceresa C. et al, (2018), HEPATOLOGY, 68, 2A - 2A
Transplantation after Viability Testing of Discarded Livers with Normothermic Machine Perfusion (NMP): The Vittal (VIability Testing and Transplantation of mArginal Livers) Trial 90-Day Outcomes
Mergental H. et al, (2018), HEPATOLOGY, 68, 1A - 1A
Urological Nephrectomies for Benign Disease: A Possible Missed Resource in Organ Donation.
Dholakia S. et al, (2018), Exp Clin Transplant