N-Terminal Proteomics in Human Glomerular Inflammation: Immunoactivity Insights and Organoid Models

Biography

Markus Rinschen, MD is an Associate Professor at the Department of Biomedicine, and Aarhus Institute for Advanced Studies, AIAS in Aarhus, Denmark as well as the III. Department of Internal Medicine University Hospital Hamburg Eppendorf, Germany. He is a Novo Nordisk Foundation Young Investigator and has received several awards, for instance the Guyton Award for Integrative Medicine and Physiology by the American Physiological Society, the Carl-Ludwig Award from the German Nephrology Society, and the Du Bois Reymond award from the German Physiological Society. He also served as an associate editor of the Journal of the American Society for Nephrology (JASN) as well as Physiological Genomics (American Physiological Society).

The laboratory of kidney omics and metabolism investigates the molecular processes that lead to chronic kidney disease. One out of ten people suffer from chronic kidney disease, an unmet burden to individuals and societies. Common causes are hypertension, diabetes, or genetic or environmental factors. Our key hypothesis is that understanding of molecular tissue pathophysiology and metabolism provides new avenues to treat and intervene with progression of chronic kidney disease. To approach this, we use a wide array of mass spectrometric, metabolic and bioinformatics tools, and integrate and benchmark big data sets with physiological function. Our results have unraveled new approaches and omics-guided targets for kidney disease in mice and men, in particular in the area of glomerular kidney disease.

Markus Rinschen studied Medicine at the University of Muenster, Germany (2004-2011), and received research training at the Laboratory of Kidney and Electrolyte Metabolism, NIH/NHLBI (2008-2009). He further trained in the II. Department of Internal Medicine, Dept of Nephrology, University of Cologne. He was also a visiting investigator at the Center for Metabolomics, Department of Chemistry, Scripps Research (2018-2020).

Recent published work includes:

1. Rinschen MM*, Gödel M, Grahammer F, Zschiedrich S, Helmstädter M, Kretz O, ..., Küttner V, Boerries M, Busch H, Schiffer M, Bergmann C, Krüger M, Hildebrandt F, Dengjel J, Benzing T*, Huber TB*. A quantitative and dynamic atlas of the native podocyte reveals novel kidney disease candidates. Cell Rep. 2018 May 22;23(8):2495-2508 * Corresponding author.

2. Höhne M, Frese CK, Grahammer F, Dafinger C, Ciarimboli G, Butt L, Binz J, Hackl MJ, Rahmatollahi M, Kann M, Schneider S, Altintas M, Schermer B, Reinheckel T, Göbel H, Reiser J, Huber TB, Kramann R, Seeger-Nukpezah T, Liebau MC, Beck BB, Benzing T, Beyer A, Rinschen MM. Single nephron proteomes connect morphology and function in proteinuric kidney disease. Kidney Int. 93(6):1308-1319, 2018.

3. Rinschen MM, Palygin O, Carlos Guijas C, Palermo A, Nicolas Palacio-Escat N, Xavier Domingo- Almenara X, Rafael Montenegro-Burke R, Julio Saez-Rodriguez J, Staruschenko A*, Siuzdak G*. Metabolic rewiring of the hypertensive kidney. Science Signaling, 2019 Dec 10;12(611):eaax9760

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