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Oxford University Hospitals (OUH) NHS Foundation Trust, North Bristol NHS Trust, and University Hospitals Coventry and Warwickshire (UHCW) NHS Trust are evaluating a new Artificial Intelligence (AI) diagnostic system that could help improve prostate cancer diagnosis.

Professor Clare Verrill and colleague using the AI pathology software
Professor Clare Verrill and colleague using the AI pathology software

In a collaborative project led by the University of Oxford, the ARTICULATE PRO study at the Nuffield Department of Surgical Sciences has today announced that another milestone has been achieved, as it has now expanded the deployment of AI in the prostate cancer pathway to three trusts, all using a computer-assisted diagnostic system called Paige Prostate Suite in the live clinical workflow across the three hospital sites. 

Each hospital uses different digital pathology scanners and information systems and serves distinct patient populations—but are all adding Paige’s AI applications to their standard of care to determine the potential to improve patient outcomes against a background of rising instances of prostate cancer.  

The Paige Prostate Suite is a diagnostic AI system comprised of three AI applications designed to help pathologists detect, grade and measure tumours in prostate biopsies and tissue samples. Pathologists at these three hospitals are assessing how Paige Prostate Suite impacts their clinical decision-making, pathology service delivery, and use of resources in a real-world setting. With this use across multiple hospitals, pathologists can assess the ways Paige’s AI technology can best serve patients, histopathologists, and hospital systems for prostate cancer diagnosis. This development is the latest achievement of the ARTICULATE PRO study, funded by the Accelerated Access Collaborative (AAC) Artificial Intelligence in Health and Care Award, overseen by the Department of Health and Social Care.

'The central focus of ARTICULATE PRO is patients. We are striving towards our goal to safely and effectively ensure they benefit the most from powerful AI technology,' said Professor Clare Verrill, OUH Cellular Pathology Consultant, Associate Professor and Principal Investigator of ARTICULATE PRO. 'With the multisite live use of The Paige Prostate Suite, we can systematically study benefits to patients in clinical settings.'

Dr Jon Oxley, uropathologist and Bristol lead of ARTICULATE PRO, added, 'I have studied the disease and progression of prostate cancer in clinical research for over 25 years, it is a significant advancement that Paige’s AI system has achieved a level of validation and performance that allows safe and effective live clinical use. Using this system alongside our standard of care has the promise to increase efficiency and improve reproducibility of results for patients.'

Dr Bidisa Sinha, uropathologist at UHCW, added, 'We believe AI can help to improve the accuracy and consistency of grading cancer and assist in detection of small areas of cancer which are easy to miss. This is world-leading research being carried out at UHCW. We are proud to be a global leader in the field of digital and computational pathology.'

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