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Uterine transplantation restores reproductive anatomy in women with absolute uterine factor infertility and allows the opportunity to conceive, experience gestation, and acquire motherhood. The number of cases being performed is increasing exponentially, with detailed outcomes from 45 cases, including nine live births, now available. In light of the data presented herein, including detailed surgical, immunosuppressive and obstetric outcomes, the feasibility of uterine transplantation is now difficult to refute. However, it is associated with significant risk with more than one-quarter of grafts removed because of complications, and one in ten donors suffering complications requiring surgical repair. TWEETABLE ABSTRACT: Uterine transplantation is feasible in women with uterine factor infertility, but is associated with significant risk of complication.

Original publication

DOI

10.1111/1471-0528.15863

Type

Journal article

Journal

BJOG

Publication Date

10/2019

Volume

126

Pages

1310 - 1319

Keywords

Gynaecology, Mayer-Rokitansky-Küster-Hauser syndrome, immunology, infertility, pregnancy, transplantation, uterus