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Osteocartilaginous metaplasia is known to occur rarely in melanomas, particularly in subungual melanomas. We present a case of a calcified subungual soft tissue tumour in which biopsy of the lesion showed malignant round and spindle-shaped tumour cells, many of which were associated with the formation of cartilage and osteoid-like material. Subsequent resection showed clear histological evidence of a subungual melanoma. Tumour cells expressed S100, melan-A and neurone-specific enolase but were negative for HMB45. Diagnostic radiological and histological features and the nature of the osteocartilaginous differentiation within this lesion is discussed.

Original publication




Journal article


Skeletal Radiol

Publication Date





724 - 727


Antigens, Neoplasm, Biomarkers, Tumor, Biopsy, Bone Neoplasms, Cartilage, Diagnosis, Differential, Fingers, Humans, MART-1 Antigen, Magnetic Resonance Imaging, Male, Melanoma, Melanoma-Specific Antigens, Middle Aged, Neoplasm Proteins, Osteochondroma, Osteosarcoma, Phosphopyruvate Hydratase, Soft Tissue Neoplasms, Tomography, X-Ray Computed