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Ischemia and reperfusion injury (IRI) is a complex pathophysiological phenomenon, inevitable in kidney transplantation and one of the most important mechanisms for non- or delayed function immediately after transplantation. Long term, it is associated with acute rejection and chronic graft dysfunction due to interstitial fibrosis and tubular atrophy. Recently, more insight has been gained in the underlying molecular pathways and signalling cascades involved, which opens the door to new therapeutic opportunities aiming to reduce IRI and improve graft survival. This review systemically discusses the specific molecular pathways involved in the pathophysiology of IRI and highlights new therapeutic strategies targeting these pathways.

Original publication

DOI

10.3390/jcm9010253

Type

Journal article

Journal

J Clin Med

Publication Date

17/01/2020

Volume

9

Keywords

adaptive immune system, apoptosis, delayed graft function, endothelial dysfunction, hypoxic inducible factor, innate immune system, ischemia reperfusion injury, kidney transplantation, necrosis