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In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale genomic, transcriptomic and epigenomic profiling of colorectal carcinomas has led to the identification of many candidate genes whose direct contribution to tumourigenesis is yet to be defined; we discuss the utility of cross-species comparative 'omics-based approaches to this problem. We highlight recent progress in modelling late-stage disease using mice, and discuss ways in which mouse models could better recapitulate the complexity of human cancers to tackle the problem of therapeutic resistance and recurrence after surgical resection.

Original publication

DOI

10.1002/bies.201500032

Type

Journal article

Journal

Bioessays

Publication Date

08/2015

Volume

37

Pages

909 - 920

Keywords

colorectal cancer, disease biomarker, mouse model, ome and omics, target identification, target validation, Animals, Antineoplastic Agents, Colorectal Neoplasms, Genes, Neoplasm, Humans, Molecular Targeted Therapy, Neoplasms, Experimental, Species Specificity, Xenograft Model Antitumor Assays