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Lyso-thermosensitive liposomes (LTSLs) are specifically designed to release chemotherapy agents under conditions of mild hyperthermia. Preclinical studies have indicated that magnetic resonance (MR)-guided focused ultrasound (FUS) systems can generate well-controlled volumetric hyperthermia using real-time thermometry. However, high-throughput clinical translation of these approaches for drug delivery is challenging, not least because of the significant cost overhead of MR guidance and the much larger volumes that need to be heated clinically. Using an ultrasound-guided extracorporeal clinical FUS device (Chongqing HAIFU, JC200) with thermistors in a non-perfused ex vivo bovine liver tissue model with ribs, we present an optimised strategy for rapidly inducing (5-15 min) and sustaining (>30 min) mild hyperthermia (ΔT

Original publication




Journal article


Ultrasound Med Biol

Publication Date





982 - 997


Drug delivery, Focused ultrasound, High-intensity focused ultrasound, Hyperthermia, Lyso-thermosensitive liposomal doxorubicin, Therapeutic ultrasound, Thermal dose, ThermoDox, Thermometry, Ultrasound, Adenocarcinoma, Animals, Antibiotics, Antineoplastic, Cattle, Colorectal Neoplasms, Cost-Benefit Analysis, Drug Delivery Systems, Humans, Hyperthermia, Induced, Liposomes, Liver, Liver Neoplasms, Ribs, Temperature, Ultrasonography, Ultrasonography, Interventional