Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

This study was intended to investigate the neural signals related to oculomotor and visual activity during horizontal saccades in humans and to explore the potential of using such signals as a functional marker for localizing the periventricular and periaqueductal gray. We recorded the local field potentials (LFPs) via implanted electrodes in the rostrolateral part of the periventricular and periaqueductal gray in four patients (six electrodes) who underwent deep brain stimulation for treatment of neuropathic pain. The functional composition of the saccade-related LFPs under different visual conditions was characterized using time-frequency analysis, and it was correlated with the anatomic placement of the electrodes on the postoperative magnetic resonance images. The magnitude of oculomotor signals varied predictably with the proximity of the recording electrode to the superior colliculus; the oculomotor activity was represented specifically in the alpha (8-13 Hz) and theta (4-8 Hz) bands for saccades and in the alpha band for fixation, whereas the visual activity was represented in the delta band (1-3 Hz) of the LFPs. The compound LFP signals of the superior colliculus embrace the synchronized population activity of multimodalities, which can be differentiated in the frequency domain. This is the first time LFP signals of the human superior colliculus have been characterized. Such signals may be used as a functional marker for electrode placement in the periventricular and periaqueductal gray for modulation of pain.

Original publication

DOI

10.1097/WNP.0b013e3181b2f2c1

Type

Journal article

Journal

J Clin Neurophysiol

Publication Date

08/2009

Volume

26

Pages

280 - 287

Keywords

Adult, Brain Mapping, Deep Brain Stimulation, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Female, Humans, Male, Middle Aged, Neuralgia, Periaqueductal Gray, Saccades, Superior Colliculi