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Prostate cancer is a major cause of mortality, largely as a consequence of metastases and transformation to androgen-independent growth. Metalloproteinases are implicated in cancer progression. A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) are expressed in prostate cancer cells, with ADAMTS-1 and ADAMTS-15 being the most abundant. ADAMTS-15 but not ADAMTS-1 expression was downregulated by androgen in LNCaP prostate cancer cells, possibly through androgen response elements associated with the gene. ADAMTS-15 expression is predictive for survival in breast cancer, and the situation may be similar in prostate cancer, as androgen independence is usually due to aberrant signaling through its receptor.

Original publication

DOI

10.3109/07357907.2010.489538

Type

Journal article

Journal

Cancer Invest

Publication Date

08/2010

Volume

28

Pages

698 - 710

Keywords

ADAM Proteins, ADAMTS Proteins, ADAMTS1 Protein, Androgens, Animals, Cell Line, Tumor, Dihydrotestosterone, Disease Progression, Gene Expression Regulation, Neoplastic, Male, Mice, Mice, Nude, Prostatic Neoplasms