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Cytosolic sulfotransferases (SULT) are involved in detoxification pathways. A functional polymorphism in the SULT1A1 gene, leading to an Arg213His substitution (SULT1A1*2), is thought to confer susceptibility to various types of cancer. Upper urinary tract urothelial cell carcinomas (UUT-UCC) are rare (5% of all urothelial carcinomas). We genotyped 268 patients with UUT-UCC and 268 healthy controls matched for age, gender, tobacco consumption, and ethnicity. His213 (SULT1A1*2) allele frequency was significantly higher in patients than in controls (37.1% versus 28.9%; P=0.004). The His/His genotype corresponding to low-activity SULT1A1 enzyme conferred a significantly higher risk of UUT-UCC (odds ratio, 2.18; 95% confidence interval, 1.28-3.69; P=0.004

Original publication

DOI

10.1158/1055-9965.EPI-07-0361

Type

Journal article

Journal

Cancer Epidemiol Biomarkers Prev

Publication Date

11/2007

Volume

16

Pages

2500 - 2503

Keywords

Adult, Aged, Aged, 80 and over, Alleles, Arylsulfotransferase, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Genetic, Urologic Neoplasms, Urothelium