Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Local excision is an established treatment for significant benign rectal tumours and early-stage cancers. It provides cure for most patients with pT1 disease, with minimum impact on quality of life. It is particularly suitable for elderly or comorbid patients. Local excision is associated with a risk of local recurrence, and this may vary from 5 to 30%, as determined by pathological risk factors. Recurrent cancer may be challenging to manage, but this may be mitigated by early detection with intensive surveillance and the use of adjuvant radiotherapy. This approach offers a realistic option for organ preservation in carefully selected early-stage disease compared with primary treatment with radiotherapy or total neoadjuvant treatment.

Original publication

DOI

10.1016/j.clon.2022.08.030

Type

Journal article

Journal

Clin Oncol (R Coll Radiol)

Publication Date

02/2023

Volume

35

Pages

82 - 86

Keywords

Early rectal cancer, local excision, organ preservation, Humans, Aged, Quality of Life, Neoplasm Staging, Rectal Neoplasms, Digestive System Surgical Procedures, Chemoradiotherapy, Neoadjuvant Therapy, Neoplasm Recurrence, Local, Treatment Outcome