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In some transplantation settings, achieving B cell as well as T cell tolerance will be essential in order to ensure long-term graft survival. However, in other situations, although B cell tolerance could potentially offer advantages to the long-term function of the graft and may therefore be desirable, there is no evidence that inducing B cell tolerance alongside T cell tolerance is essential. This overview forms part of a debate discussing the potential role of B cell tolerance in transplantation and uses selected examples in the literature to address the question: is B cell tolerance essential for transplantation tolerance?

Type

Journal article

Journal

Transplantation

Publication Date

15/02/2005

Volume

79

Pages

S40 - S42

Keywords

Acute Disease, Animals, Antibody Formation, B-Lymphocytes, Graft Rejection, Humans, Immune Tolerance, T-Lymphocytes, Transplantation Immunology, Transplantation, Homologous