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T helper (Th) type 17 cells are a recently described CD4 T-cell subset that may contribute to allograft rejection and act as a barrier to the induction of transplant tolerance. This review examines the involvement of Th17 cells in transplant rejection, how immunosuppressive medication may affect their induction and maintenance and the potential plasticity of developing Th17 cells. It also addresses the complex interplay between the Th17 and regulatory T-cell developmental pathways and the susceptibility of Th17 cells to regulation. Despite accumulating evidence, the precise impact of Th17 cells on transplant rejection and the induction of tolerance require further clarification.

Original publication

DOI

10.1097/TP.0b013e3182126eeb

Type

Journal article

Journal

Transplantation

Publication Date

15/05/2011

Volume

91

Pages

939 - 945

Keywords

Animals, Autoimmune Diseases, Drug Resistance, Graft Rejection, Humans, Immunosuppressive Agents, Mice, Models, Immunological, Signal Transduction, T-Lymphocytes, Regulatory, Th1 Cells, Th17 Cells, Transplantation Tolerance, Transplantation, Homologous