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Coronary revascularisation using cardiopulmonary bypass remains the gold standard treatment for coronary artery disease. Over the past decade, techniques of revascularisation on the beating heart without the use of cardiopulmonary bypass (off-pump surgery) have evolved with an attempt to reduce the potential deleterious effects of extracorporeal circulation. Several trials have reported a significant reduction in morbidity with avoidance of cardiopulmonary bypass, while large observational studies have also reported a reduction in mortality. Complete avoidance of aortic manipulation by using off-pump techniques and composite grafts may add an additional benefit particularly in patients at highest risk of stroke. The impact of this mode of revascularisation has probably been underestimated especially in an era where surgical revascularisation is being increasingly undertaken in older patients with significant comorbidities. In this contribution, the current evidence from randomised trials, meta-analyses and observational studies is critically reviewed.

Original publication




Journal article


Eur J Cardiothorac Surg

Publication Date





312 - 321


Acute Kidney Injury, Brain Injuries, Cardiopulmonary Bypass, Coronary Artery Bypass, Off-Pump, Coronary Disease, Evidence-Based Medicine, Humans, Meta-Analysis as Topic, Randomized Controlled Trials as Topic, Review Literature as Topic, Systemic Inflammatory Response Syndrome