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Drugs using inhibitors of mammalian target of rapamycin provide a real opportunity to treat patients with much lower exposure to calcineurin inhibitors. Long-term studies remain to be completed that show whether this might lead to important reductions in drug-related kidney damage. Evidence is starting to accumulate that the use of a mammalian target of rapamycin inhibitor early after transplantation might be contraindicated because of impairment in tubular regeneration. © 2004 Lippincott Williams & Wilkins.

Original publication




Journal article


Current Opinion in Organ Transplantation

Publication Date





361 - 368