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A 60-year-man presented with painful gynaecomastia and polycythaemia due to a beta-human chorionic gonadotropin (HCG)-secreting clear cell renal cell carcinoma. A computed tomographic scan of his chest, abdomen and pelvis showed an enhancing 9x9 cm mass in the right kidney suggestive of a renal cell carcinoma. He underwent right radical nephrectomy and the histology showed a clear cell renal cell carcinoma. Following his nephrectomy, over the next 6 months, his gynaecomastia regressed and serum beta-HCG levels became undetectable. Nine months after his nephrectomy, he developed a paratesticular lesion involving scrotal skin, for which he underwent a right radical orchidectomy. Histopathology of the paratesticular lesion showed metastatic renal cell carcinoma.

Original publication




Journal article


Scand J Urol Nephrol

Publication Date





555 - 557


Biomarkers, Tumor, Carcinoma, Renal Cell, Chorionic Gonadotropin, Diagnosis, Differential, Follow-Up Studies, Gynecomastia, Humans, Kidney Neoplasms, Male, Middle Aged, Paraneoplastic Syndromes, Tomography, X-Ray Computed