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Decreasing the incidence of chronic rejection and reducing the need for life-long immunosuppression remain important goals in clinical transplantation. In this article, we will review how regulatory T cells (Treg) came to be recognized as an attractive way to prevent or treat allograft rejection, the ways in which Treg can be manipulated or expanded in vivo, and the potential of in vitro expanded/generated Treg for cellular therapy. We will describe the first regulatory T cell therapies that have been or are in the process of being conducted in the clinic as well as the safety concerns of such therapies and how outcomes may be measured.

Original publication

DOI

10.1016/j.smim.2011.04.001

Type

Journal article

Journal

Semin Immunol

Publication Date

08/2011

Volume

23

Pages

304 - 313

Keywords

Animals, Cell- and Tissue-Based Therapy, Chemotherapy, Adjuvant, Clinical Trials as Topic, Europe, Graft Rejection, Humans, Immunomodulation, Organ Transplantation, T-Lymphocytes, Regulatory, Transplantation Tolerance, Treatment Outcome