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Beta-cell replacement either by pancreatic organ or islet cell transplantation is the only treatment to achieve an insulin-independent, normoglycemic state and to avoid hypoglycemic episodes in patients with type 1 diabetes mellitus. This article will review the state-of-the-art in clinical islet cell transplantation at the dawn of the new millennium and will provide an outlook on the basis of extended personal experience.

Original publication

DOI

10.1055/s-2001-18597

Type

Journal article

Journal

Exp Clin Endocrinol Diabetes

Publication Date

2001

Volume

109 Suppl 2

Pages

S384 - S399

Keywords

Graft Rejection, Humans, International Cooperation, Islets of Langerhans Transplantation, Registries