Prevention of postoperative recurrence of Crohn's disease
Van Loo ES., Dijkstra G., Ploeg RJ., Nieuwenhuijs VB.
Background: Up to 75% of patients with Crohn's disease (CD) will have intestinal resection during their life. Most patients will, however, develop postoperative recurrence (endoscopic, clinical or surgical). Several medical and surgical strategies have been attempted to prevent postoperative recurrence. This review evaluates the efficacy of different drug regimens and surgical techniques in the prevention of clinical, endoscopic and surgical postoperative recurrence of CD. Methods: A literature search for randomized controlled trials on medical or surgical interventions was performed. The endpoints for efficacy were clinical, endoscopic and surgical recurrence. Meta-analyses were performed in case two or more RCTs evaluated the same drug or surgical technique. Results: Mesalamine is more effective in preventing clinical recurrence than placebo (P. =. 0,012), as well as nitroimidazolic antibiotics at one year follow-up (P.