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We have demonstrated that micro-channel electrode arrays with 100 microm x 100 microm cross-section channels support axon regeneration well, and that micro-channels of similar calibre and up to 5 mm long can support axon regeneration and vascularisation. They may be microfabricated using silicon, silicone, or polyimide and thin metal films to form 3-D bundles of long micro-channels. Arrays of "mini-nerves," i.e., miniature nerve fascicles with their own blood vessels, successfully grew through implants 0.5-5 mm long. Furthermore, guiding the regenerating nerve fibres into the small insulating channels allows for a significant increase of the extracellular (recordable) amplitude of action potentials, which promises considerable improvement for in vivo electrophysiology.

Original publication




Journal article


IEEE Trans Neural Syst Rehabil Eng

Publication Date





454 - 460


Action Potentials, Animals, Electrodes, Implanted, Equipment Design, Equipment Failure Analysis, Guided Tissue Regeneration, Male, Microelectrodes, Nerve Regeneration, Rats, Reproducibility of Results, Sciatic Neuropathy, Sensitivity and Specificity