Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Neuroendocrine tumors (NETs) (previously termed carcinoids) are slow-growing tumors of the neuroendocrine system. They can occur anywhere within the body but are most commonly found in the midgut. This review is therefore confined to a discussion of gastroenteropancreatic NETS (GEP-NETS). GEP-NETS may be asymptomatic and are found incidentally (eg, during appendicectomy) or can present with symptoms attributable to either the site of the primary tumor or the secretion of serotonin and other substances from metastatic carcinoid disease (carcinoid syndrome). Symptoms of carcinoid syndrome include facial flushing, diarrhea, wheezing, colicky abdominal pain, and edema. Surgical resection offers the only curative treatment for neuroendocrine tumors, although peptide hormone analogues can be used to control carcinoid symptoms. Guidelines exist to determine when further surgical resection is required when NETs (carcinoids) are found incidentally during appendicectomy. A multi-disciplinary approach is essential for the management of all children with these rare and challenging tumors.

Original publication

DOI

10.1053/j.sempedsurg.2014.03.007

Type

Journal article

Journal

Semin Pediatr Surg

Publication Date

04/2014

Volume

23

Pages

91 - 95

Keywords

Appendix, Carcinoid, GEP-NET, Neuroendocrine tumor, Pancreas, Carcinoid Tumor, Child, Combined Modality Therapy, Gastrointestinal Neoplasms, Humans, Neuroendocrine Tumors, Pancreatic Neoplasms, Treatment Outcome