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PURPOSE OF REVIEW: Cell-based immunotherapy offers a novel approach to minimize the need for immunosuppressive drugs and to promote a state of immunological tolerance to a transplanted organ. We review the most promising biomarkers and functional assays able to identify patients tolerant to their graft. Such a signature of tolerance is essential in the assessment of the efficacy with which trials of cellular therapies promote immunoregulation and minimize graft rejection. RECENT FINDINGS: A multitude of novel cellular therapies have entered early-phase clinical trials in solid-organ transplant patients. Recent multicentre collaborations have enabled the determination of distinct tolerance profiles for both liver and kidney transplant recipients. These have been shown to be highly predictive of tolerance in certain settings and show utility in identifying patients in whom immunosuppressive drugs can be weaned or discontinued. SUMMARY: In order to become a viable treatment option in solid-organ transplantation, the latest large, multicentre clinical trials of cellular therapies must utilize, validate and discover the biomarkers with the capacity to reliably identify a signature of immune tolerance.

Original publication

DOI

10.1097/MOT.0000000000000154

Type

Journal article

Journal

Curr Opin Organ Transplant

Publication Date

02/2015

Volume

20

Pages

64 - 71

Keywords

Animals, Biological Assay, Biomarkers, Cell- and Tissue-Based Therapy, Graft Rejection, Humans, Immune Tolerance, Organ Transplantation, Transplantation Tolerance