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The literature covering neurotensin (NT) and its signalling pathways, receptors, and biological profile is complicated by the fact that the discovery of three NT receptor subtypes has come to light only in recent years. Moreover, a lot of this literature explores NT in the context of the central nervous system and behavioral studies. However, there is now good evidence that the up-regulation of NT is intimately involved in cancer development and progression. This Review aims to summarize the isolation, cloning, localization, and binding properties of the accepted receptor subtypes (NTR1, NTR2, and NTR3) and the molecules known to bind at these receptors. The growing role these targets are playing in cancer research is also discussed. We hope this Review will provide a useful overview and a one-stop resource for new researchers engaged in this field at the chemistry-biology interface.

Original publication

DOI

10.1021/cb900038e

Type

Journal article

Journal

ACS Chem Biol

Publication Date

17/07/2009

Volume

4

Pages

503 - 525

Keywords

Animals, Biomarkers, Disease Progression, Humans, Neoplasms, Protein Binding, Receptors, Neurotensin