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PURPOSE: The aim of this study was to investigate the specific anti-tumour immunity of cytotoxic T lymphocytes (CTL) activated by high-intensity focused ultrasound (HIFU) after adoptive transfer in a murine tumour model. MATERIALS AND METHODS: H22 tumour-bearing mice were treated by either HIFU or sham-HIFU, while naïve syngeneic mice were used as controls. They were sacrificed and the spleens were harvested 14 days after HIFU. T lymphocytes were obtained from the spleens, and then adoptively transferred into 40 mice each bearing a 3-day implanted H22 tumour. On day 14 after adoptive transfer, 10 mice were sacrificed in each group for assessment of the number of tumour-infiltrating T lymphocytes and interferon-gamma (IFN-γ) secreting cells. The remaining 30 mice were continuously observed for 60 days, and tumour growth, progression and survival were recorded. RESULTS: HIFU significantly increased peripheral blood CD3(+), CD4(+) levels and CD4(+)/CD8(+) ratio (P 

Original publication




Journal article


Int J Hyperthermia

Publication Date





204 - 210


Cytotoxic T lymphocyte, high-intensity focused ultrasound, immunotherapy, thermal ablation, tumour, Animals, Cell Line, Tumor, Female, High-Intensity Focused Ultrasound Ablation, Immunotherapy, Adoptive, Mice, Mice, Inbred C57BL, Neoplasms, T-Lymphocytes, Cytotoxic