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Arterial grafts have long-term patency superior to vein grafts but have a tendency to develop spasm that can lead to potentially life-threatening complications. A perfect antispastic protocol should include advanced surgical technique and adequate pharmacologic methods. All pharmacologic vasodilator drugs relax the vessel through specific mechanisms, and therefore, there is no perfect, single best vasodilator to prevent or treat spasm of the arterial graft against all mechanisms of contraction. One of the choices is to use a combination of pharmacologic vasodilators targeting different mechanisms of spasm to obtain the reliable and best effect.

Original publication




Journal article


Ann Thorac Surg

Publication Date





659 - 668


Coronary Artery Bypass, Coronary Artery Disease, Graft Occlusion, Vascular, Humans, Radial Artery, Vascular Patency, Vasodilator Agents