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PURPOSE: Previous studies indicate a possible inverse relationship between prostate-specific antigen (PSA) and body mass index (BMI), and a positive relationship between PSA and age. We investigated the associations between age, BMI, PSA, and screen-detected prostate cancer to determine whether an age-BMI-adjusted PSA model would be clinically useful for detecting prostate cancer. METHODS: Cross-sectional analysis nested within the UK ProtecT trial of treatments for localized cancer. Of 18,238 men aged 50-69 years, 9,457 men without screen-detected prostate cancer (controls) and 1,836 men with prostate cancer (cases) met inclusion criteria: no history of prostate cancer or diabetes; PSA 0.2). The age-BMI-adjusted PSA model performed as well as an age-adjusted model based on National Institute for Health and Care Excellence (NICE) guidelines at detecting prostate cancer. CONCLUSIONS: Age and BMI were associated with small changes in PSA. An age-BMI-adjusted PSA model is no more clinically useful for detecting prostate cancer than current NICE guidelines. Future studies looking at the effect of different variables on PSA, independent of their effect on prostate cancer, may improve the discrimination of PSA for prostate cancer.

Original publication




Journal article


Cancer Causes Control

Publication Date





1465 - 1474


Age, BMI, PSA, PSA–BMI equation, Prostate cancer, Prostate cancer screening, Age Factors, Aged, Body Mass Index, Case-Control Studies, Cross-Sectional Studies, Early Detection of Cancer, Humans, Kallikreins, Male, Middle Aged, Obesity, Prostate-Specific Antigen, Prostatic Neoplasms, Randomized Controlled Trials as Topic, United Kingdom