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Prostate cancer treatment is dominated by strategies to control androgen receptor (AR) activity. AR has an impact on prostate cancer development through the regulation of not only transcription networks but also genomic stability and DNA repair, as manifest in the emergence of gene fusions. Whole-genome maps of AR binding sites and transcript profiling have shown changes in the recruitment and regulatory effect of AR on transcription as prostate cancer progresses. Defining other factors that are involved in this reprogramming of AR function gives various opportunities for cancer detection and therapeutic intervention.

Original publication

DOI

10.1038/nrc3678

Type

Journal article

Journal

Nat rev cancer

Publication Date

03/2014

Volume

14

Pages

187 - 198

Keywords

Animals, Gene Expression Regulation, Neoplastic, Humans, Male, Prostatic Neoplasms, Receptors, Androgen, Transcription, Genetic