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Internalization of cargo proteins and lipids at the cell surface occurs in both a constitutive and signal-regulated manner through clathrin-mediated and other endocytic pathways. Clathrin-coated vesicle formation is a principal uptake route in response to signalling events. Protein-lipid and protein-protein interactions control both the targeting of signalling molecules and their binding partners to membrane compartments and the assembly of clathrin coats. An emerging aspect of membrane trafficking research is now addressing how signalling cascades and vesicle coat assembly and subsequently disassembly are integrated.

Original publication




Journal article


Semin Cell Dev Biol

Publication Date





459 - 470


Adaptor Proteins, Vesicular Transport, Animals, Cell Cycle, Clathrin-Coated Vesicles, Coated Pits, Cell-Membrane, Endocytosis, Humans, Protein Processing, Post-Translational, Receptor, Epidermal Growth Factor, Signal Transduction