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γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.

Original publication

DOI

10.1097/TP.0000000000002335

Type

Journal article

Journal

Transplantation

Publication Date

12/2018

Volume

102

Pages

1983 - 1993

Keywords

Animals, Graft Rejection, Graft Survival, Hematopoietic Stem Cell Transplantation, Humans, Organ Transplantation, Phenotype, Receptors, Antigen, T-Cell, gamma-delta, Signal Transduction, T-Lymphocyte Subsets, Transplantation Tolerance, Treatment Outcome