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γδ T cells are a subpopulation of lymphocytes expressing heterodimeric T-cell receptors composed of γ and δ chains. They are morphologically and functionally heterogeneous, innate yet also adaptive in behavior, and exhibit diverse activities spanning immunosurveillance, immunomodulation, and direct cytotoxicity. The specific responses of γδ T cells to allografts are yet to be fully elucidated with evidence of both detrimental and tolerogenic roles in different settings. Here we present an overview of γδ T-cell literature, consider ways in which their functional heterogeneity contributes to the outcomes after transplantation, and reflect on methods to harness their beneficial properties.

Original publication




Journal article



Publication Date





1983 - 1993


Animals, Graft Rejection, Graft Survival, Hematopoietic Stem Cell Transplantation, Humans, Organ Transplantation, Phenotype, Receptors, Antigen, T-Cell, gamma-delta, Signal Transduction, T-Lymphocyte Subsets, Transplantation Tolerance, Treatment Outcome