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Publications

Improving radiotherapy in immunosuppressive microenvironments by targeting complement receptor C5aR1.

Beach C. et al, (2023), J Clin Invest

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

Chan DKH. et al, (2023)

CARE: Protocol of a randomised trial evaluating the feasibility of preoperative intentional weight loss to support postoperative recovery in patients with excess weight and colorectal cancer.

Koutoukidis DA. et al, (2023), Colorectal Dis

Biallelic FBXW7 knockout induces AKAP8-mediated DNA damage in neighbouring wildtype cells.

Chan DKH. et al, (2023), Cell Death Discov, 9

Generation and immunofluorescent validation of gene knockouts in adult human colonic organoids using multi-guide RNA CRISPR-Cas9

Chan DKH. et al, (2023), STAR Protocols, 4, 101978 - 101978

APOBEC mutagenesis is a common process in normal human small intestine.

Wang Y. et al, (2023), Nat Genet

FXR inhibition may protect from SARS-CoV-2 infection by reducing ACE2.

Brevini T. et al, (2022), Nature

Inherited MUTYH mutations cause elevated somatic mutation rates and distinctive mutational signatures in normal human cells

Robinson PS. et al, (2022), Nature Communications, 13

Mutational landscape of normal epithelial cells in Lynch Syndrome patients

Lee BCH. et al, (2022), Nature Communications, 13

An innate IL-25–ILC2–MDSC axis creates a cancer-permissive microenvironment for Apc mutation–driven intestinal tumorigenesis

Jou E. et al, (2022), Science Immunology, 7

Stage migration – a negative quality indicator in colon cancer management

Chan DKH. and Buczacki SJA., (2022), Colorectal Disease, 24, 153 - 154

Primary tumour immune response and lymph node yields in colon cancer.

Lal N. et al, (2022), Br J Cancer

Cancer Stem Cells

Damavandi MD. et al, (2022), Encyclopedia of Cell Biology: Volume 1-6, Second Edition, 6, 114 - 123

FXR AS A NEW THERAPEUTIC TARGET FOR COVID-19

Brevini T. et al, (2021), HEPATOLOGY, 74, 318A - 318A

FXR ANTAGONISTS AS NEW AGENTS FOR COVID19

Brevini T. et al, (2021), GUT, 70, A4 - A4

Tumour heterogeneity and evolutionary dynamics in colorectal cancer

Chan DKH. and Buczacki SJA., (2021), Oncogenesis, 10

Targeting acid ceramidase to improve the radiosensitivity of rectal cancer

Clifford R. et al, (2020), Cells

5-hydroxymethylcytosine and gene activity in mouse intestinal differentiation

Uribe-Lewis S. et al, (2020), Scientific Reports, 10

An analysis of SARS-CoV-2 cell entry genes identifies the intestine and colorectal cancer as susceptible tissues.

Darvish-Damavandi M. et al, (2020), Br J Surg

The use of oral antibiotics and mechanical bowel preparation in elective colorectal resection for the reduction of surgical site infection

Duff SE. et al, (2020), Colorectal Disease, 22, 364 - 372

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