A Phase Ib/II study of IGF-neutralising antibody xentuzumab with enzalutamide in metastatic castration-resistant prostate cancer.
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CHK1 inhibition exacerbates replication stress induced by IGF blockade
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Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction.
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IGF targeting perturbs global replication through ribonucleotide reductase dysfunction.
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Type 1 IGF receptor associates with adverse outcome and cellular radioresistance in paediatric high-grade glioma.
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Dual-specificity protein phosphatase DUSP4 regulates response to MEK inhibition in BRAF wild-type melanoma.
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Radioresistant laryngeal cancers upregulate type 1 IGF receptor and exhibit increased cellular dependence on IGF and EGF signalling.
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Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy.
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Bad to the Bone: The Role of the Insulin-Like Growth Factor Axis in Osseous Metastasis.
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Nuclear IGF1R Interacts with Regulatory Regions of Chromatin to Promote RNA Polymerase II Recruitment and Gene Expression Associated with Advanced Tumor Stage.
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RAPTOR up-regulation contributes to resistance of renal cancer cells to PI3K-mTOR inhibition.
Earwaker P. et al, (2018), PLoS One, 13
IGF-1R associates with adverse outcomes after radical radiotherapy for prostate cancer.
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Insulin-Like Growth Factor (IGF) Pathway Targeting in Cancer: Role of the IGF Axis and Opportunities for Future Combination Studies.
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