Short study title: LINX vs Fundoplication
Study acronym: GOLF
Double-blind randomised controlled trial for treatment of Gastro-Oesophageal reflux disease; LINX management system vs. Fundoplication
Key information
Does the LINX procedure achieve similar reflux control and improve postoperative symptoms, specifically gas bloating and inability to belch, when compared to laparoscopic fundoplication?
Programme name: NIHR-Efficacy and Mechanism Evaluation (EME)
Sponsor: University of Oxford
Trial duration: 01/07/2023 to 30/06/2028 (60 months)
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The GOLF is coming at the perfect time following recent level 1 NICE guidance for LINX. This trial is the first RCT to directly compare LINX and fundoplication and which operation is better for our patients.
- Mr Paul Goldsmith, Consultant General and Oesophagogastric Surgery, Central Manchester University Hospital NHS Foundation Trust
FOR PARTICIPANTS
Find out more about what it means to take part.
FOR pARTICIPATING SITES
Schedule of events, recruitment and resources.
Message from the Chief Investigator
This important international RCT will aim to improve the long-term health related quality of life for patients with gastro-oesophageal reflux disease through comparison of two established surgical treatments; fundoplication and the LINX procedure. We are hugely excited to undertake this RCT and define the gold standard surgical treatment for gastro-oesophageal reflux disease. - Professor Sheraz R. Markar, Director, Surgical Intervention Trials Unit, University of Oxford
This study is the first large project of its kind to see whether the LINX procedure will give patients less side effects compared to fundoplication. We hope that patients who have the LINX procedure will benefit from feeling less bloating and enables them to burp freely which can be distressing for those effected, but we need the GOLF study to test if this is the case or not. The study will ensure that we have the evidence to show which procedure - LINX or fundoplication - is best in helping to control acid reflux in patients. For patients who do not want to have surgery, or it has not successfully controlled their symptoms, this is an exciting step forward. I am delighted to be part of this study. It is a major step forward in ensuring patients get the best surgical treatment for their acid reflux. - Mimi McCord, Chairman, Trustee & Director, Heartburn Cancer UK