The SENTINEL study
Chief Investigator
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PROFESSOR HENK GIELEConsultant Plastic Surgeon |
Oxford Research in Plastic surgery and Hand surgery Innovation Collaboration (ORPHIC)
What are we trying to find out?
The aim of the SENTINEL study is to find out whether there is a lower risk of organ rejection in lung transplant, if a small patch of skin (called a sentinel skin flap) from the same donor is transplanted at the same time as the lung.
Click below to find out how
The skin will be transplanted onto the under-surface of the lower arm
Monitoring for rejection
The skin flap is always visible, and can show if lung rejection is occurring by showing a red rash. Currently, rejection can only be shown by doing a biopsy of the transplanted lung.
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The skin flap allows us to check for rejection.
What will happen in the study?
We will collect some information about you whilst you are on the waiting list and ask you to fill in some questionnaires.
When you are offered a lung transplant, we will confirm your participation. You will then be put into one of two groups (randomised), one of the groups will receive a skin flap with their lung transplant and one will not.
Once you have had your transplant, we will collect data and some samples from you for 12 months.
More details are in the full information pack which will be sent to patients on the waiting list by their clinical team.
Cardiothoracic Centres Taking part
OPEN to recruitment at:
Freeman Hospital, Harefield Hospital, Queen Elizabeth Hospital, Royal Papworth Hospital
Opening soon:
Wythenshawe Hospital
Patient and Public Involvement and Engagement (PPIE)
In partnership with
