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Department of Neurosurgery, West Wing, Level 3, John Radcliffe Hospital, Oxford OX3 9DU
I studied medicine at University College London qualifying MB BS in 1997. I obtained a first class honours in Neurosciences (intercalated) in 1994. After house jobs and a basic surgical rotation in the West Midlands, I entered Neurusurgical training in London then Oxford from 2002-2009. I completed a MD degree in Oxford in the role of the periaqueductal grey area in autonomic control during this time. I became a consultant neurosurgeon in 2009. I am currently president of the British Society for Stereotactic and Functional Neurosurgery (BSSFN).
Awards Training and Qualifications
- FRCS (SN) Royal College of Surgeons of England2007
- Doctor of Medicine University of London 2005- 2007
- MB BS University College London 1991- 1997
- BSc (Hons) University College London 1994
- New Investigator Award International Neuromodulation Society 2010
- 7th Cluster Headache Award International Annual Convention on Cluster Headache 2010
- Stereotactic and Functional Neurosurgery Resident Award Congress of Neurological Surgeons (USA) 2005
- Gordon Holmes Prize Royal Society of Medicine 2005
Spalding Associate Professor and Co-deputy Director of SITU
- Consultant Neurosurgeon
Over the past six years I have been looking at the neurocircuitry underlying autonomic function and pain in humans undergoing Deep Brain Stimulation (DBS). There are several aims of this research. Firstly, I wish to understand both the mechanisms underlying the pathophysiology of neuropathic pain as well as why some patients get much better than results than others. Secondly, by understanding the autonomic nervous system, it may be possible to control diseases such as hypertension, respiratory and bladder disease by brain manipulation in the future. Most of the research to date has involved stimulating brain areas under different experimental conditions and also recording local field potentials to understand the underlying neurophysiology. This work has resulted in a number of publications including improvement in peak expiratory flow with stimulation, the effect of stimulation on blood pressure and baroreceptors sensitivity and novel electrical signals associated with pain states.
Sources of Funding
- BRC 2009-2014
- British Heart Foundation 2011-2012
- European Union FP7 2012-2015
Deep Brain Stimulation and Levodopa Affect Gait Variability in Parkinson Disease Differently.
Su ZH. et al, (2022), Neuromodulation
DyNeuMo Mk-1: Design and pilot validation of an investigational motion-adaptive neurostimulator with integrated chronotherapy.
Zamora M. et al, (2022), Exp Neurol, 351
Probabilistic Mapping Reveals Optimal Stimulation Site in Essential Tremor.
Nowacki A. et al, (2022), Ann Neurol, 91, 602 - 612
Deep brain stimulation of the nucleus accumbens in severe enduring anorexia nervosa: a pilot study
SCAIFE J. et al, (2022), Frontiers in Behavioral Neuroscience
Spatial and Temporal Distribution of Information Processing in the Human Dorsal Anterior Cingulate Cortex.
Keogh C. et al, (2022), Front Hum Neurosci, 16