- Asymptomatic Carotid Surgery Trial 2 (ACST-2) Research Group
Surgical Grand Rounds
Professor Alison Halliday discusses 'Vascular Trials, Big Data, Stroke and Dementia', as part of the Surgical Grand Rounds Lecture Series.
Professor of Vascular Surgery
I am a Principal Investigator in the Asymptomatic Carotid Surgery Trial (ACST-2), one of the world's largest clinical surgery trials, involving thousands of patients from 30 countries. Our group reported that prophylactic surgery removing tight carotid artery narrowing (carotid endarterectomy) prevents future fatal and disabling strokes for at least 10 years. This finding has changed worldwide surgical and stroke practice (Lancet 2004, 2010).
National Audit: Our group instigated and reported the UK Carotid Surgery Audit (2005-8), the largest National Audit of carotid surgery in the UK. This work highlighted shortcomings in the NHS process of referral and of carrying out prompt carotid artery surgery; we work with the National Stroke Strategy providing a driver for preventing stroke by improving surgical services (British Medical Journal, 2009).
Collaborative research; government-funded (NIHR): I work with the University of Oxford Clinical Trial Service Unit (CTSU) evaluating two stroke prevention technologies in ACST-2, a large international trial comparing Carotid Endarterectomy with Carotid Artery Stenting. This work enables surgeons, stroke physicians, neurologists, cardiologists and interventional radiologists from many countries to work together.
The Asymptomatic Carotid Surgery Trial-2 (ACST-2): An ongoing randomised trial comparing carotid endarterectomy with carotid artery stenting to prevent stroke
Halliday AW. and Bulbulia R., (2017), Health Technology Assessment, 21
Erratum to "Choices of Stent and Cerebral Protection in the Ongoing ACST-2 Trial: A Descriptive Study" [Eur J Vasc Endovasc Surg 53 (2017) 617-625].
de Waard DD. et al, (2017), Eur J Vasc Endovasc Surg, 54
Pre-operative Carotid Plaque Echolucency Assessment has no Predictive Value for Long-Term Risk of Stroke or Cardiovascular Death in Patients Undergoing Carotid Endarterectomy.
de Waard D. et al, (2017), Eur J Vasc Endovasc Surg, 54, 135 - 141
Informed consent in randomised controlled trials: development and preliminary evaluation of a measure of Participatory and Informed Consent (PIC).
Wade J. et al, (2017), Trials, 18
Quantification of Lipid-Rich Core in Carotid Atherosclerosis Using Magnetic Resonance T2 Mapping: Relation to Clinical Presentation.
Chai JT. et al, (2017), JACC Cardiovasc Imaging, 10, 747 - 756