Professor of Vascular Surgery
I am a Principal Investigator in the Asymptomatic Carotid Surgery Trial (ACST-2), one of the world's largest clinical surgery trials, involving thousands of patients from 30 countries. Our group reported that prophylactic surgery removing tight carotid artery narrowing (carotid endarterectomy) prevents future fatal and disabling strokes for at least 10 years. This finding has changed worldwide surgical and stroke practice (Lancet 2004, 2010).
National Audit: Our group instigated and reported the UK Carotid Surgery Audit (2005-8), the largest National Audit of carotid surgery in the UK. This work highlighted shortcomings in the NHS process of referral and of carrying out prompt carotid artery surgery; we work with the National Stroke Strategy providing a driver for preventing stroke by improving surgical services (British Medical Journal, 2009).
Collaborative research; government-funded (NIHR): I work with the University of Oxford Clinical Trial Service Unit (CTSU) evaluating two stroke prevention technologies in ACST-2, a large international trial comparing Carotid Endarterectomy with Carotid Artery Stenting. This work enables surgeons, stroke physicians, neurologists, cardiologists and interventional radiologists from many countries to work together.
Timing of procedural stroke and death in asymptomatic patients undergoing carotid endarterectomy: individual patient analysis from four RCTs.
Poorthuis MHF. et al, (2020), Br J Surg
Sex-Specific Associations of Vascular Risk Factors With Abdominal Aortic Aneurysm: Findings From 1.5 Million Women and 0.8 Million Men in the United States and United Kingdom.
Carter JL. et al, (2020), J Am Heart Assoc, 9
A systematic review and meta-analysis of complication rates following carotid procedures performed by different specialties
Poorthuis M. et al, (2019), Journal of Vascular Surgery
Associations of Perioperative Variables With the 30-Day Risk of Stroke or Death in Carotid Endarterectomy for Symptomatic Carotid Stenosis
HALLIDAY ALISON. et al, (2019), ahajournals.org
Timing of procedural stroke and death in asymptomatic patients undergoing carotid endarterectomy: analysis of VACS, ACAS, ACST-1 and GALA RCTs
Poorthuis M. et al, (2019), British Journal of Surgery