Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), Churchill Hospital, Oxford OX3 7LE
My research interest is to reduce hypoxia-induced damage in human islets of Langerhans during pancreas procurement, after isolation and subsequent to transplantation.
During the last years we identified perfluorohexyloctane as an efficient oxygen carrier for human pancreas preservation. This substance is characterised by increased lipophilicity and lower gravity compared to already established compounds and recently obtained approval for clinical use. We are currently aiming to develop an emulsion that combines the characteristics of both hyperoxygen carriers and organ preservation solutions.
In contrast to whole pancreases isolated islets can easily be treated during cell culture to increase their resistance toward hypoxia-induced damage prior to and after transplantation into recipients. Currently, we investigate whether islet susceptiblity toward hypoxia can be reduced by inducing intrinsic mechanisms for stress resistance or by using potentially protective substances.
The ischaemic preconditioning paradox and its implications for islet isolation from heart-beating and non heart-beating donors.
Brandhorst D. et al, (2022), Sci Rep, 12
A highly oxygenated hydrogel enhanced the survival of human islets encapsulated within macroencapsulation devices
Domingo-Lopez DA. et al, (2022), DIABETOLOGIA, 65, S92 - S92
Comparison of different hyaluronic acid-based matrices to maintain human islet survival in macroencapsulation devices
Brandhorst D. et al, (2022), DIABETOLOGIA, 65, S198 - S199
Basement membrane proteins improve human islet survival in hypoxia: Implications for islet inflammation.
Brandhorst D. et al, (2022), Acta Biomater, 137, 92 - 102
High Concentrations of Etanercept Reduce Human Islet Function and Integrity.
Brandhorst D. et al, (2021), J Inflamm Res, 14, 599 - 610